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2012 ; 2012
(ä): 161-7
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Making a diagnosis of VWD
#MMPMID23233576
Branchford BR
; Di Paola J
Hematology Am Soc Hematol Educ Program
2012[]; 2012
(ä): 161-7
PMID23233576
show ga
A clear understanding of the molecular basis of VWD can guide the choice and
interpretation of appropriate diagnostic tests. This review briefly describes the
lifecycle and molecular interactions of VWF and how they lead to the current
clinical classification. It also includes a brief discussion of the differential
diagnosis and general workup of mucocutaneous bleeding, a review of the various
VWD subtypes, and pertinent laboratory assays for each, including genetic tests.
Finally, common testing pitfalls and diagnostic dilemmas are covered, including
the challenge created by the overlap of borderline low VWF levels and mild
bleeding.