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2017 ; 13
(ä): 331-335
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Maintenance of redox homeostasis by hypoxia-inducible factors
#MMPMID28624704
Samanta D
; Semenza GL
Redox Biol
2017[Oct]; 13
(ä): 331-335
PMID28624704
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Oxidative phosphorylation enables cells to generate the large amounts of ATP
required for development and maintenance of multicellular organisms. However,
under conditions of reduced O(2) availability, electron transport becomes less
efficient, leading to increased generation of superoxide anions.
Hypoxia-inducible factors switch cells from oxidative to glycolytic metabolism,
to reduce mitochondrial superoxide generation, and increase the synthesis of
NADPH and glutathione, in order to maintain redox homeostasis under hypoxic
conditions.