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2015 ; 15
(6
): 12983-98
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Magnetic-particle-sensing based diagnostic protocols and applications
#MMPMID26053747
Takamura T
; Ko PJ
; Sharma J
; Yukino R
; Ishizawa S
; Sandhu A
Sensors (Basel)
2015[Jun]; 15
(6
): 12983-98
PMID26053747
show ga
Magnetic particle-labeled biomaterial detection has attracted much attention in
recent years for a number of reasons; easy manipulation by external magnetic
fields, easy functionalization of the surface, and large surface-to-volume ratio,
to name but a few. In this review, we report on our recent investigations into
the detection of nano-sized magnetic particles. First, the detection by Hall
magnetic sensor with lock-in amplifier and alternative magnetic field is
summarized. Then, our approach to detect sub-200 nm diameter target magnetic
particles via relatively large micoro-sized "columnar particles" by optical
microscopy is described. Subsequently, we summarize magnetic particle detection
based on optical techniques; one method is based on the scattering of the
magnetically-assembled nano-sized magnetic bead chain in rotating magnetic fields
and the other one is based on the reflection of magnetic target particles and
porous silicon. Finally, we report recent works with reference to more familiar
industrial products (such as smartphone-based medical diagnosis systems and
magnetic removal of unspecific-binded nano-sized particles, or "magnetic
washing").