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10.1007/978-1-4939-3148-4_3 http://scihub22266oqcxt.onion/10.1007/978-1-4939-3148-4_3 C4870594!4870594 !26530913     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26530913 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Methods+Mol+Biol 2016 ; 1372 (ä): 37-47 Nephropedia Template TP {{tp|p=26530913 |t=2016. Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy |pdf=|usr=}}{{26530913 }} gab.com Text Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy JO: Methods Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26530913 #FOAvip Small interfering RNA (siRNA) is routinely used as a biological tool to silence specific genes, and is under active investigation in cancer treatment strategies. Noninvasive magnetic resonance spectroscopy (MRS) provides the ability to assess the functional effects of siRNA-mediated gene silencing in cultured cancer cells, and following nanoparticle-based delivery in tumors in vivo. Here we describe the use of siRNA to downregulate choline kinase, a critical enzyme in choline phospholipid metabolism of cancer cells and tumors, and the use of (1)H MRS of cells and (1)H magnetic resonance spectroscopic imaging (MRSI) of tumors to assess the efficacy of the downregulation. Twit Text FOAVip Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy ????Methods Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26530913 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26530913 #FOAvip English Wikipedia <ref>{{Cite pmid|26530913 }}</ref> Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy #MMPMID26530913 Penet MF ; Chen Z ; Mori N ; Krishnamachary B ; Bhujwalla ZM Methods Mol Biol 2016[]; 1372 (ä): 37-47 PMID26530913 show ga Small interfering RNA (siRNA) is routinely used as a biological tool to silence specific genes, and is under active investigation in cancer treatment strategies. Noninvasive magnetic resonance spectroscopy (MRS) provides the ability to assess the functional effects of siRNA-mediated gene silencing in cultured cancer cells, and following nanoparticle-based delivery in tumors in vivo. Here we describe the use of siRNA to downregulate choline kinase, a critical enzyme in choline phospholipid metabolism of cancer cells and tumors, and the use of (1)H MRS of cells and (1)H magnetic resonance spectroscopic imaging (MRSI) of tumors to assess the efficacy of the downregulation. |Animals [MESH] |Cell Line, Tumor [MESH] |Choline Kinase/genetics [MESH] |Disease Models, Animal [MESH] |Gene Expression [MESH] |Gene Transfer Techniques [MESH] |Humans [MESH] |Magnetic Resonance Spectroscopy/*methods [MESH] |Mice [MESH] |Mice, SCID [MESH] |Molecular Imaging/*methods [MESH] |Nanoparticles/chemistry [MESH] |Neoplasms/*genetics/*therapy [MESH] |RNA, Small Interfering/administration & dosage/chemistry/*genetics [MESH] |Transfection [MESH]Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy (epmc).pdf DeepDyve Pubget Overpricing