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2011 ; 2
(1
): 5-26
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Magnetic Resonance Imaging of Cartilage Repair: A Review
#MMPMID26069565
Trattnig S
; Winalski CS
; Marlovits S
; Jurvelin JS
; Welsch GH
; Potter HG
Cartilage
2011[Jan]; 2
(1
): 5-26
PMID26069565
show ga
Articular cartilage lesions are a common pathology of the knee joint, and many
patients may benefit from cartilage repair surgeries that offer the chance to
avoid the development of osteoarthritis or delay its progression. Cartilage
repair surgery, no matter the technique, requires a noninvasive, standardized,
and high-quality longitudinal method to assess the structure of the repair
tissue. This goal is best fulfilled by magnetic resonance imaging (MRI). The
present article provides an overview of the current state of the art of MRI of
cartilage repair. In the first 2 sections, preclinical and clinical MRI of
cartilage repair tissue are described with a focus on morphological depiction of
cartilage and the use of functional (biochemical) MR methodologies for the
visualization of the ultrastructure of cartilage repair. In the third section, a
short overview is provided on the regulatory issues of the United States Food and
Drug Administration (FDA) and the European Medicines Agency (EMEA) regarding MR
follow-up studies of patients after cartilage repair surgeries.