Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\18568054
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Biochem+Rev
2003 ; 24
(2
): 47-66
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Magnesium metabolism and its disorders
#MMPMID18568054
Swaminathan R
Clin Biochem Rev
2003[May]; 24
(2
): 47-66
PMID18568054
show ga
Magnesium is the fourth most abundant cation in the body and plays an important
physiological role in many of its functions. Magnesium balance is maintained by
renal regulation of magnesium reabsorption. The exact mechanism of the renal
regulation is not fully understood. Magnesium deficiency is a common problem in
hospital patients, with a prevalence of about 10%. There are no readily available
and easy methods to assess magnesium status. Serum magnesium and the magnesium
tolerance test are the most widely used. Measurement of ionised magnesium may
become more widely available with the availability of ion selective electrodes.
Magnesium deficiency and hypomagnesaemia can result from a variety of causes
including gastrointestinal and renal losses. Magnesium deficiency can cause a
wide variety of features including hypocalcaemia, hypokalaemia and cardiac and
neurological manifestations. Chronic low magnesium state has been associated with
a number of chronic diseases including diabetes, hypertension, coronary heart
disease, and osteoporosis. The use of magnesium as a therapeutic agent in asthma,
myocardial infarction, and pre-eclampsia is also discussed. Hypermagnesaemia is
less frequent than hypomagnesaemia and results from failure of excretion or
increased intake. Hypermagnesaemia can lead to hypotension and other
cardiovascular effects as well as neuromuscular manifestations. Causes and
management of hypermagnesaemia are discussed.
free
free
free
