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2012 ; 5
(Suppl 1
): i25-i38
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Magnesium in disease
#MMPMID26069818
Geiger H
; Wanner C
Clin Kidney J
2012[Feb]; 5
(Suppl 1
): i25-i38
PMID26069818
show ga
Although the following text will focus on magnesium in disease, its role in
healthy subjects during physical exercise when used as a supplement to enhance
performance is also noteworthy. Low serum magnesium levels are associated with
metabolic syndrome, Type 2 diabetes mellitus (T2DM) and hypertension;
consequently, some individuals benefit from magnesium supplementation: increasing
magnesium consumption appears to prevent high blood pressure, and higher serum
magnesium levels are associated with a lower risk of developing a metabolic
syndrome. There are, however, conflicting study results regarding magnesium
administration with myocardial infarction with and without reperfusion therapy.
There was a long controversy as to whether or not magnesium should be given as a
first-line medication. As the most recent trials have not shown any difference in
outcome, intravenous magnesium cannot be recommended in patients with myocardial
infarction today. However, magnesium has its indication in patients with torsade
de pointes and has been given successfully to patients with digoxin-induced
arrhythmia or life-threatening ventricular arrhythmias. Magnesium sulphate as an
intravenous infusion also has an important established therapeutic role in
pregnant women with pre-eclampsia as it decreases the risk of eclamptic seizures
by half compared with placebo.
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