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2015 ; 7
(9
): 8199-226
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English Wikipedia
Magnesium in Prevention and Therapy
#MMPMID26404370
Gröber U
; Schmidt J
; Kisters K
Nutrients
2015[Sep]; 7
(9
): 8199-226
PMID26404370
show ga
Magnesium is the fourth most abundant mineral in the body. It has been recognized
as a cofactor for more than 300 enzymatic reactions, where it is crucial for
adenosine triphosphate (ATP) metabolism. Magnesium is required for DNA and RNA
synthesis, reproduction, and protein synthesis. Moreover, magnesium is essential
for the regulation of muscular contraction, blood pressure, insulin metabolism,
cardiac excitability, vasomotor tone, nerve transmission and neuromuscular
conduction. Imbalances in magnesium status-primarily hypomagnesemia as it is seen
more common than hypermagnesemia-might result in unwanted neuromuscular, cardiac
or nervous disorders. Based on magnesium's many functions within the human body,
it plays an important role in prevention and treatment of many diseases. Low
levels of magnesium have been associated with a number of chronic diseases, such
as Alzheimer's disease, insulin resistance and type-2 diabetes mellitus,
hypertension, cardiovascular disease (e.g., stroke), migraine headaches, and
attention deficit hyperactivity disorder (ADHD).