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2019 ; 2019
(ä): 7908205
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Magnesium Enhances Osteogenesis of BMSCs by Tuning Osteoimmunomodulation
#MMPMID31828131
Zhang X
; Chen Q
; Mao X
Biomed Res Int
2019[]; 2019
(ä): 7908205
PMID31828131
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In the process of bone tissue engineering, the osteoimmunomodulatory property of
biomaterials is very important for osteogenic differentiation of stem cells,
which determines the outcome of bone regeneration. Magnesium (Mg) is a
biodegradable, biocompatible metal that has osteoconductive properties and has
been regarded as a promising bone biomaterial. However, the high degradation rate
of Mg leads to excessive inflammation, thereby restricting its application in
bone tissue engineering. Importantly, different coatings or magnesium alloys have
been utilized to lower the rate of degradation. In fact, a prior study proved
that ?-TCP coating of Mg scaffolds can modulate the osteoimmunomodulatory
properties of Mg-based biomaterials and create a favorable immune
microenvironment for osteogenesis. However, the osteoimmunomodulatory properties
of Mg ions themselves have not been explored yet. In this study, the
osteoimmunomodulatory properties of Mg ions with involvement of macrophages and
bone marrow stem cells (BMSCs) were systematically investigated. Microscale Mg
ions (100?mg/L) were found to possess osteoimmunomodulatory properties that favor
bone formation. Specifically, microscale Mg ions induced M2 phenotype changes of
macrophages and the release of anti-inflammatory cytokines by inhibiting the
TLR-NF-?B signaling pathway. Microscale Mg ions also stimulated the expression of
osteoinductive molecules in macrophages while Mg ions/macrophage-conditioned
medium promoted osteogenesis of BMSCs through the BMP/SMAD signaling pathway.
These findings indicate that manipulating Mg ion concentration can endow the Mg
biomaterial with favorable osteoimmunomodulatory properties, thereby providing
fundamental evidence for improving and modifying the effect of Mg-based bone
biomaterials.
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