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2016 ; 38
(4
): 461-9
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Macrophage-epithelial interactions in pulmonary alveoli
#MMPMID27170185
Bhattacharya J
; Westphalen K
Semin Immunopathol
2016[Jul]; 38
(4
): 461-9
PMID27170185
show ga
Alveolar macrophages have been investigated for years by approaches involving
macrophage extraction from the lung by bronchoalveolar lavage, or by cell removal
from lung tissue. Since extracted macrophages are studied outside their natural
milieu, there is little understanding of the extent to which alveolar macrophages
interact with the epithelium, or with one another to generate the lung's innate
immune response to pathogen challenge. Here, we review new evidence of
macrophage-epithelial interactions in the lung, and we address the emerging
understanding that the alveolar epithelium plays an important role in
orchestrating the macrophage-driven immune response.