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2015 ; 2
(1
): ä Nephropedia Template TP
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Macrophage polarization in kidney diseases
#MMPMID26082946
Tian S
; Chen SY
Macrophage (Houst)
2015[]; 2
(1
): ä PMID26082946
show ga
Macrophage accumulation associates closely with the degree of renal structural
injury and renal dysfunction in human kidney diseases. Depletion of macrophages
reduces while adoptive transfer of macrophages worsens inflammation in animal
models of the renal injury. However, emerging evidence support that macrophage
polarization plays a critical role in the progression of a number of kidney
diseases including obstructive nephropathy, ischemia-reperfusion injury,
glomerulonephritis, diabetic nephropathy, and other kidney diseases. In this
mini-review, we briefly summarize the macrophage infiltration and polarization in
these inflammatory and fibrotic kidney diseases, discussing the results mostly
from studies in animal models. In view of the critical role of macrophage in the
progression of these diseases, manipulating macrophage phenotype may be a
potential effective strategy to treat various kidney diseases.