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2014 ; 10
(5
): 520-9
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Macrophage polarization in inflammatory diseases
#MMPMID24910531
Liu YC
; Zou XB
; Chai YF
; Yao YM
Int J Biol Sci
2014[]; 10
(5
): 520-9
PMID24910531
show ga
Diversity and plasticity are two hallmarks of macrophages. M1 macrophages
(classically activated macrophages) are pro-inflammatory and have a central role
in host defense against infection, while M2 macrophages (alternatively activated
macrophages) are associated with responses to anti-inflammatory reactions and
tissue remodeling, and they represent two terminals of the full spectrum of
macrophage activation. Transformation of different phenotypes of macrophages
regulates the initiation, development, and cessation of inflammatory diseases.
Here we reviewed the characters and functions of macrophage polarization in
infection, atherosclerosis, obesity, tumor, asthma, and sepsis, and proposed that
targeting macrophage polarization and skewing their phenotype to adapt to the
microenvironment might hold great promise for the treatment of inflammatory
diseases.
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