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10.18632/oncotarget.21653 http://scihub22266oqcxt.onion/10.18632/oncotarget.21653 C5685744!5685744 !29163823     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29163823 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29163823 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (52 ): 90225-90237 Nephropedia Template TP {{tp|p=29163823 |t=2017. MYC is downregulated by a mitochondrial checkpoint mechanism |pdf=|usr=}}{{29163823 }} gab.com Text MYC is downregulated by a mitochondrial checkpoint mechanism JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29163823 #FOAvip The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. Here we describe a novel link between mitochondria and MYC levels. Perturbation of mitochondrial function using a number of conventional and novel inhibitors resulted in the decreased expression of MYC mRNA. This decrease in MYC mRNA occurred concomitantly with an increase in the levels of tumor-suppressive miRNAs such as members of the let-7 family and miR-34a-5p. Knockdown of let-7 family or miR-34a-5p could partially restore MYC levels following mitochondria damage. We also identified let-7-dependent downregulation of the MYC mRNA chaperone, CRD-BP (coding region determinant-binding protein) as an additional control following mitochondria damage. Our data demonstrates the existence of a homeostasis mechanism whereby mitochondrial function controls MYC expression. Twit Text FOAVip MYC is downregulated by a mitochondrial checkpoint mechanism ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29163823 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29163823 #FOAvip English Wikipedia <ref>{{Cite pmid|29163823 }}</ref> MYC is downregulated by a mitochondrial checkpoint mechanism #MMPMID29163823 Zhang X ; Mofers A ; Hydbring P ; Olofsson MH ; Guo J ; Linder S ; D'Arcy P Oncotarget 2017[Oct]; 8 (52 ): 90225-90237 PMID29163823 show ga The MYC proto-oncogene serves as a rheostat coupling mitogenic signaling with the activation of genes regulating growth, metabolism and mitochondrial biogenesis. Here we describe a novel link between mitochondria and MYC levels. Perturbation of mitochondrial function using a number of conventional and novel inhibitors resulted in the decreased expression of MYC mRNA. This decrease in MYC mRNA occurred concomitantly with an increase in the levels of tumor-suppressive miRNAs such as members of the let-7 family and miR-34a-5p. Knockdown of let-7 family or miR-34a-5p could partially restore MYC levels following mitochondria damage. We also identified let-7-dependent downregulation of the MYC mRNA chaperone, CRD-BP (coding region determinant-binding protein) as an additional control following mitochondria damage. Our data demonstrates the existence of a homeostasis mechanism whereby mitochondrial function controls MYC expression. äMYC is downregulated by a mitochondrial checkpoint mechanism (epmc).pdf DeepDyve Pubget Overpricing