Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24591536
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Cold Spring Harb Perspect Med
2014[Mar]; 4
(3
): ? PMID24591536
show ga
The MYC oncoprotein is an essential transcription factor that regulates the
expression of many genes involved in cell growth, proliferation, and metabolic
pathways. Thus, it is important to keep MYC activity in check in normal cells in
order to avoid unwanted oncogenic changes. Normal cells have adapted several ways
to control MYC levels, and these mechanisms can be disrupted in cancer cells. One
of the major ways in which MYC levels are controlled in cells is through targeted
degradation by the ubiquitin-proteasome system (UPS). Here, we discuss the role
of the UPS in the regulation of MYC protein levels and review some of the many
proteins that have been shown to regulate MYC protein stability. In addition, we
discuss how this relates to MYC transcriptional activity, human cancers, and
therapeutic targeting.
free
free
free
