Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24789872
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cold+Spring+Harb+Perspect+Med
2014 ; 4
(5
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
MYC and mitochondrial biogenesis
#MMPMID24789872
Morrish F
; Hockenbery D
Cold Spring Harb Perspect Med
2014[May]; 4
(5
): ä PMID24789872
show ga
Mitochondria, the powerhouses of the cell, face two imperatives concerning
biogenesis. The first is the requirement for dividing cells to replicate their
mitochondrial content by growth of existing mitochondria. The second is the
dynamic regulation of mitochondrial content in response to organismal and
cellular cues (e.g., exercise, caloric restriction, energy status, temperature).
MYC provides the clearest example of a programmed expansion of mitochondrial
content linked to the cell cycle. As an oncogene, MYC also presents intriguing
questions about the role of its mitochondrial targets in cancer-related
phenotypes, such as the Warburg effect and MYC-dependent apoptosis.