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10.1016/j.bbcan.2014.01.001 http://scihub22266oqcxt.onion/10.1016/j.bbcan.2014.01.001 C4045475!4045475 !24418575     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24418575 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24418575 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochim+Biophys+Acta 2014 ; 1845 (2 ): 126-35 Nephropedia Template TP {{tp|p=24418575 |t=2014. MUC1: a novel metabolic master regulator |pdf=|usr=}}{{24418575 }} gab.com Text MUC1: a novel metabolic master regulator JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24418575 #FOAvip MUC1, a type I transmembrane protein, is significantly overexpressed and aberrantly glycosylated in tumors of epithelial origin. By virtue of its aberrant signaling due to loss of apical-basal polarity in cancer, MUC1 regulates the metabolite flux at multiple levels. Serving as a transcriptional co-activator, MUC1 directly regulates expression of metabolic genes. By regulating receptor tyrosine kinase signaling, MUC1 facilitates production of biosynthetic intermediates required for cell growth. Also, via direct interactions, MUC1 modulates the activity/stability of enzymes and transcription factors that directly regulate metabolic functions. Additionally, by modulation of autophagy, levels of reactive oxygen species, and metabolite flux, MUC1 facilitates cancer cell survival under hypoxic and nutrient-deprived conditions. This article provides a comprehensive review of recent literature on novel metabolic functions of MUC1. Twit Text FOAVip MUC1: a novel metabolic master regulator ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24418575 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24418575 #FOAvip English Wikipedia <ref>{{Cite pmid|24418575 }}</ref> MUC1: a novel metabolic master regulator #MMPMID24418575 Mehla K ; Singh PK Biochim Biophys Acta 2014[Apr]; 1845 (2 ): 126-35 PMID24418575 show ga MUC1, a type I transmembrane protein, is significantly overexpressed and aberrantly glycosylated in tumors of epithelial origin. By virtue of its aberrant signaling due to loss of apical-basal polarity in cancer, MUC1 regulates the metabolite flux at multiple levels. Serving as a transcriptional co-activator, MUC1 directly regulates expression of metabolic genes. By regulating receptor tyrosine kinase signaling, MUC1 facilitates production of biosynthetic intermediates required for cell growth. Also, via direct interactions, MUC1 modulates the activity/stability of enzymes and transcription factors that directly regulate metabolic functions. Additionally, by modulation of autophagy, levels of reactive oxygen species, and metabolite flux, MUC1 facilitates cancer cell survival under hypoxic and nutrient-deprived conditions. This article provides a comprehensive review of recent literature on novel metabolic functions of MUC1. |*Gene Expression Regulation, Neoplastic [MESH] |Autophagy/genetics [MESH] |Cell Survival [MESH] |Humans [MESH] |Mucin-1/biosynthesis/*genetics/*metabolism [MESH] |Neoplasms/genetics/*metabolism/pathology [MESH] |Phosphorylation/genetics [MESH] |Reactive Oxygen Species/metabolism [MESH] |Signal Transduction/genetics [MESH]MUC1: a novel metabolic master regulator (epmc).pdf DeepDyve Pubget Overpricing