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2014 ; 9
(ä): 12
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MSARC: Multiple sequence alignment by residue clustering
#MMPMID24735785
Modzelewski M
; Dojer N
Algorithms Mol Biol
2014[]; 9
(ä): 12
PMID24735785
show ga
BACKGROUND: Progressive methods offer efficient and reasonably good solutions to
the multiple sequence alignment problem. However, resulting alignments are biased
by guide-trees, especially for relatively distant sequences. RESULTS: We propose
MSARC, a new graph-clustering based algorithm that aligns sequence sets without
guide-trees. Experiments on the BAliBASE dataset show that MSARC achieves
alignment quality similar to the best progressive methods. Furthermore, MSARC
outperforms them on sequence sets whose evolutionary distances are difficult to
represent by a phylogenetic tree. These datasets are most exposed to the
guide-tree bias of alignments. AVAILABILITY: MSARC is available at
http://bioputer.mimuw.edu.pl/msarc.