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2015 ; 3
(6
): 475-489
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MRI/MRS in neuroinflammation: methodology and applications
#MMPMID26705534
Quarantelli M
Clin Transl Imaging
2015[]; 3
(6
): 475-489
PMID26705534
show ga
Neuroinflammation encompasses a wide range of humoral and cellular responses, not
only enabling the CNS to fight various noxious events, including infections and
trauma, but also playing a critical role in autoimmune as well as in
neurodegenerative diseases. The complex interactions of immune, endothelial, and
neuronal cells that take place during inflammation require an equivalent
complexity of imaging approaches to be appropriately explored in vivo. Magnetic
Resonance provides several complementary techniques that allow to study most
mechanisms underlying the brain/immune interaction. In this review, we discuss
the MR approaches to the study of endothelial activation, blood-brain barrier
permeability alterations, intercellular compartment modifications, immune cell
trafficking, and of metabolic alterations linked to immune cell activity. The
main advantages and limitations of these techniques are assessed, in view of
their exploitation in the clinical arena, where the complementarity of the
information that can be obtained has the potential to change our way of studying
neuroinflammation, with implications for the management of several CNS diseases.
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