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2015 ; 2015
(ä): 786802
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MRI for Crohn s Disease: Present and Future
#MMPMID26413543
Yoon K
; Chang KT
; Lee HJ
Biomed Res Int
2015[]; 2015
(ä): 786802
PMID26413543
show ga
Crohn's disease (CD) is a chronic inflammatory condition with relapsing-remitting
behavior, often causing strictures or penetrating bowel damage. Its lifelong
clinical course necessitates frequent assessment of disease activity and
complications. Computed tomography (CT) enterography has been used as primary
imaging modality; however, the concern for radiation hazard limits its use
especially in younger population. Magnetic resonance (MR) imaging has advantages
of avoiding radiation exposure, lower incidence of adverse events, ability to
obtain dynamic information, and good soft-tissue resolution. MR enterography
(MRE) with oral contrast agent has been used as primary MR imaging modality of CD
with high sensitivity, specificity, and interobserver agreement. The extent of
inflammation as well as transmural ulcers and fibrostenotic diseases can be
detected with MRE. Novel MR techniques such as diffusion-weighted MRI (DWI),
motility study, PET-MRI, and molecular imaging are currently investigated for
further improvement of diagnosis and management of CD. MR spectroscopy is a
remarkable molecular imaging tool to analyze metabolic profile of CD with human
samples such as plasma, urine, or feces, as well as colonic mucosa itself.
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