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10.1186/1752-0509-8-58 http://scihub22266oqcxt.onion/10.1186/1752-0509-8-58 C4045882!4045882 !24886436     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24886436 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24886436 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Syst+Biol 2014 ; 8 (ä): 58 Nephropedia Template TP {{tp|p=24886436 |t=2014. MP-Align: alignment of metabolic pathways |pdf=|usr=}}{{24886436 }} gab.com Text MP-Align: alignment of metabolic pathways JO: BMC Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=24886436 #FOAvip BACKGROUND: Comparing the metabolic pathways of different species is useful for understanding metabolic functions and can help in studying diseases and engineering drugs. Several comparison techniques for metabolic pathways have been introduced in the literature as a first attempt in this direction. The approaches are based on some simplified representation of metabolic pathways and on a related definition of a similarity score (or distance measure) between two pathways. More recent comparative research focuses on alignment techniques that can identify similar parts between pathways. RESULTS: We propose a methodology for the pairwise comparison and alignment of metabolic pathways that aims at providing the largest conserved substructure of the pathways under consideration. The proposed methodology has been implemented in a tool called MP-Align, which has been used to perform several validation tests. The results showed that our similarity score makes it possible to discriminate between different domains and to reconstruct a meaningful phylogeny from metabolic data. The results further demonstrate that our alignment algorithm correctly identifies subpathways sharing a common biological function. CONCLUSION: The results of the validation tests performed with MP-Align are encouraging. A comparison with another proposal in the literature showed that our alignment algorithm is particularly well-suited to finding the largest conserved subpathway of the pathways under examination. Twit Text FOAVip MP-Align: alignment of metabolic pathways ????BMC Syst Biol http://www.kidney.de/pget.php?&tw=1&pmid=24886436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24886436 #FOAvip English Wikipedia <ref>{{Cite pmid|24886436 }}</ref> MP-Align: alignment of metabolic pathways #MMPMID24886436 Alberich R ; Llabrés M ; Sánchez D ; Simeoni M ; Tuduri M BMC Syst Biol 2014[May]; 8 (ä): 58 PMID24886436 show ga BACKGROUND: Comparing the metabolic pathways of different species is useful for understanding metabolic functions and can help in studying diseases and engineering drugs. Several comparison techniques for metabolic pathways have been introduced in the literature as a first attempt in this direction. The approaches are based on some simplified representation of metabolic pathways and on a related definition of a similarity score (or distance measure) between two pathways. More recent comparative research focuses on alignment techniques that can identify similar parts between pathways. RESULTS: We propose a methodology for the pairwise comparison and alignment of metabolic pathways that aims at providing the largest conserved substructure of the pathways under consideration. The proposed methodology has been implemented in a tool called MP-Align, which has been used to perform several validation tests. The results showed that our similarity score makes it possible to discriminate between different domains and to reconstruct a meaningful phylogeny from metabolic data. The results further demonstrate that our alignment algorithm correctly identifies subpathways sharing a common biological function. CONCLUSION: The results of the validation tests performed with MP-Align are encouraging. A comparison with another proposal in the literature showed that our alignment algorithm is particularly well-suited to finding the largest conserved subpathway of the pathways under examination. |*Metabolic Networks and Pathways [MESH] |Algorithms [MESH] |Computational Biology/*methods [MESH] |Computer Graphics [MESH] |Glycolysis [MESH] |Reproducibility of Results [MESH]MP-Align: alignment of metabolic pathways (epmc).pdf DeepDyve Pubget Overpricing