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10.1007/s12551-010-0039-y http://scihub22266oqcxt.onion/10.1007/s12551-010-0039-y C5425679!5425679 !28510038     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28510038 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biophys+Rev 2010 ; 2 (4 ): 169-179 Nephropedia Template TP {{tp|p=28510038 |t=2010. MOLS sampling and its applications in structural biophysics |pdf=|usr=}}{{28510038 }} gab.com Text MOLS sampling and its applications in structural biophysics JO: Biophys Rev http://www.kidney.de/pget.php?&tw=1&pmid=28510038 #FOAvip This review describes the MOLS method and its applications. This computational method has been developed in our laboratory primarily to explore the conformational space of small peptides and identify features of interest, particularly the minima, i.e., the low energy conformations. A systematic "brute-force" search through the vast conformational space for such features faces the insurmountable problem of combinatorial explosion, whilst other techniques, e.g., Monte Carlo searches, are somewhat limited in their region of exploration and may be considered inexhaustive. The MOLS method, on the other hand, uses a sampling technique commonly employed in experimental design theory to identify a small sample of the conformational space that nevertheless retains information about the entire space. The information is extracted using a technique that is a variant of the self-consistent mean field technique, which has been used to identify, for example, the optimal set of side-chain conformations in a protein. Applications of the MOLS method to understand peptide structure, predict the structures of loops in proteins, predict three-dimensional structures of small proteins, and arrive at the best conformation, orientation, and positions of a small molecule ligand in a protein receptor site have all yielded satisfactory results. Twit Text FOAVip MOLS sampling and its applications in structural biophysics ????Biophys Rev http://www.kidney.de/pget.php?&tw=1&pmid=28510038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28510038 #FOAvip English Wikipedia <ref>{{Cite pmid|28510038 }}</ref> MOLS sampling and its applications in structural biophysics #MMPMID28510038 Ramya L ; Nehru Viji S ; Arun Prasad P ; Kanagasabai V ; Gautham N Biophys Rev 2010[Dec]; 2 (4 ): 169-179 PMID28510038 show ga This review describes the MOLS method and its applications. This computational method has been developed in our laboratory primarily to explore the conformational space of small peptides and identify features of interest, particularly the minima, i.e., the low energy conformations. A systematic "brute-force" search through the vast conformational space for such features faces the insurmountable problem of combinatorial explosion, whilst other techniques, e.g., Monte Carlo searches, are somewhat limited in their region of exploration and may be considered inexhaustive. The MOLS method, on the other hand, uses a sampling technique commonly employed in experimental design theory to identify a small sample of the conformational space that nevertheless retains information about the entire space. The information is extracted using a technique that is a variant of the self-consistent mean field technique, which has been used to identify, for example, the optimal set of side-chain conformations in a protein. Applications of the MOLS method to understand peptide structure, predict the structures of loops in proteins, predict three-dimensional structures of small proteins, and arrive at the best conformation, orientation, and positions of a small molecule ligand in a protein receptor site have all yielded satisfactory results. äMOLS sampling and its applications in structural biophysics (epmc).pdf DeepDyve Pubget Overpricing