Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\30038300
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cell+Death+Dis
2018 ; 9
(8
): 796
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
METTL3 regulates WTAP protein homeostasis
#MMPMID30038300
Sorci M
; Ianniello Z
; Cruciani S
; Larivera S
; Ginistrelli LC
; Capuano E
; Marchioni M
; Fazi F
; Fatica A
Cell Death Dis
2018[Jul]; 9
(8
): 796
PMID30038300
show ga
The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors,
including, acute myeloid leukemia (AML), where it plays an oncogenic role by
interacting with different proteins involved in RNA processing and cell
proliferation. In addition, WTAP is also a regulator of the nuclear complex
required for the deposition of N(6)-methyladenosine (m6A) into mRNAs, containing
the METTL3 methyltransferase. However, it is not clear if WTAP may have
m6A-independent regulatory functions that might contribute to its oncogenic role.
Here, we show that both knockdown and overexpression of METTL3 protein results in
WTAP protein upregulation, indicating that METTL3 levels are critical for WTAP
protein homeostasis. However, we show that WTAP upregulation is not sufficient to
promote cell proliferation in the absence of a functional METTL3. Therein, these
data indicate that the reported oncogenic function of WTAP is strictly connected
to a functional m6A methylation complex.
free
free
free
