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10.1007/s13238-013-3048-3

http://scihub22266oqcxt.onion/10.1007/s13238-013-3048-3
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C4875528!4875528!23836153
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suck abstract from ncbi


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pmid23836153      Protein+Cell 2013 ; 4 (9): 643-6
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  • MED12 mutations in human diseases #MMPMID23836153
  • Wang H; Shen Q; Ye Lh; Ye J
  • Protein Cell 2013[Sep]; 4 (9): 643-6 PMID23836153show ga
  • The Mediator Complex plays key roles in activating gene transcription in eukaryotes. Mediator of RNA polymerase II transcription subunit 12 homolog (MED12) is a subunit of the Mediator Complex and regulates the activity of the complex. MED12 is involved in a variety of cellular activities, and mutations in MED12 gene impair MED12 activities and are associated with several diseases, including Opitz-Kaveggia syndrome, Lujan syndrome, uterine leiomyomas and prostate cancer. This review will discuss the biological function of MED12 and the relationship between MED12 mutations and diseases.
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