Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25001534.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Exp+Med+Biol 2014 ; 818 (ä): 127-53 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
MDA-7/IL-24: Multifunctional Cancer Killing Cytokine #MMPMID25001534
Menezes ME; Bhatia S; Bhoopathi P; Das SK; Emdad L; Dasgupta S; Dent P; Wang XY; Sarkar D; Fisher PB
Adv Exp Med Biol 2014[]; 818 (ä): 127-53 PMID25001534show ga
First identified almost two decades ago as a novel gene differentially expressed in human melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great potential as an anti-cancer gene. MDA-7/IL24, a secreted protein of the IL-10 family, functions as a cytokine at normal physiological levels and is expressed in tissues of the immune system. At supra-physiological levels, MDA-7/IL-24 plays a prominent role in inhibiting tumor growth, invasion, metastasis and angiogenesis and was recently shown to target tumor stem/initiating cells for death. Much of the attention focused on MDA-7/IL-24 originated from the fact that it can selectively induce cell death in cancer cells without affecting normal cells. Thus, this gene originally shown to be associated with melanoma cell differentiation has now proven to be a multi-functional protein affecting a broad array of cancers. Moreover, MDA-7/IL-24 has proven efficacious in a Phase I/II clinical trial in humans with multiple advanced cancers. As research in the field progresses, we will unravel more of the functions of MDA-7/IL-24 and define novel ways to utilize MDA-7/IL-24 in the treatment of cancer.
free
free
free
Adv+Exp+Med+Biol 2014 ; 818 (ä): 127-53
