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2015 ; 5
(ä): 18448
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MCO Membranes: Enhanced Selectivity in High-Flux Class
#MMPMID26669756
Boschetti-de-Fierro A
; Voigt M
; Storr M
; Krause B
Sci Rep
2015[Dec]; 5
(ä): 18448
PMID26669756
show ga
Novel MCO high-flux membranes for hemodialysis have been developed with optimized
permeability, allowing for filtration close to that of the natural kidney. A
comprehensive in vitro characterization of the membrane properties by dextran
filtration is presented. The sieving profile of pristine membranes, as well as
that of membranes exposed to blood for 40?minutes, are described. The effective
pore size (Stokes-Einstein radius) was estimated from filtration experiments
before and after blood exposure, and results were compared to hydrodynamic radii
of middle and large uremic toxins and essential proteins. The results indicate
that the tailored pore sizes of the MCO membranes promote removal of large toxins
while ensuring the retention of albumin.