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2015 ; 5
(7
): 686-97
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Lymphatic imaging: focus on imaging probes
#MMPMID25897334
Niu G
; Chen X
Theranostics
2015[]; 5
(7
): 686-97
PMID25897334
show ga
In view of the importance of sentinel lymph nodes (SLNs) in tumor staging and
patient management, sensitive and accurate imaging of SLNs has been intensively
explored. Along with the advance of the imaging technology, various contrast
agents have been developed for lymphatic imaging. In this review, the lymph node
imaging agents were summarized into three groups: tumor targeting agents,
lymphatic targeting agents and lymphatic mapping agents. Tumor targeting agents
are used to detect metastatic tumor tissue within LNs, lymphatic targeting agents
aim to visualize lymphatic vessels and lymphangionesis, while lymphatic mapping
agents are mainly for SLN detection during surgery after local administration.
Coupled with various signal emitters, these imaging agents work with single or
multiple imaging modalities to provide a valuable way to evaluate the location
and metastatic status of SLNs.
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