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2014 ; 21
(6
): 496-506
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Lung xenotransplantation: recent progress and current status
#MMPMID25040467
Harris DG
; Quinn KJ
; Dahi S
; Burdorf L
; Azimzadeh AM
; Pierson RN 3rd
Xenotransplantation
2014[Nov]; 21
(6
): 496-506
PMID25040467
show ga
Xenotransplantation has undergone important progress in controlling initial
hyperacute rejection in many preclinical models, with some cell, tissue, and
organ xenografts advancing toward clinical trials. However, acute injury, driven
primarily by innate immune and inflammatory responses, continues to limit results
in lung xenograft models. The purpose of this article is to review the current
status of lung xenotransplantation--including the seemingly unique challenges
posed by this organ-and summarize proven and emerging means of overcoming acute
lung xenograft injury.