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2015 ; 12 Suppl 1
(Suppl 1
): S30-3
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Lung extracellular matrix and fibroblast function
#MMPMID25830832
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Ann Am Thorac Soc
2015[Mar]; 12 Suppl 1
(Suppl 1
): S30-3
PMID25830832
show ga
Extracellular matrix (ECM) is a tissue-specific macromolecular structure that
provides physical support to tissues and is essential for normal organ function.
In the lung, ECM plays an active role in shaping cell behavior both in health and
disease by virtue of the contextual clues it imparts to cells. Qualities
including dimensionality, molecular composition, and intrinsic stiffness all
promote normal function of the lung ECM. Alterations in composition and/or
modulation of stiffness of the focally injured or diseased lung ECM
microenvironment plays a part in reparative processes performed by fibroblasts.
Under conditions of remodeling or in disease states, inhomogeneous stiffening (or
softening) of the pathologic ECM may both precede modifications in cell behavior
and be a result of disease progression. The ability of ECM to stimulate further
ECM production by fibroblasts and drive disease progression has potentially
significant implications for mesenchymal stromal cell-based therapies; in the
setting of pathologic ECM stiffness or composition, the therapeutic intent of
progenitor cells may be subverted. Taken together, current data suggest that lung
ECM actively contributes to health and disease; thus, mediators of cell-ECM
signaling or factors that influence ECM stiffness may represent viable
therapeutic targets in many lung disorders.
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