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2016 ; 13 Suppl 1
(Suppl 1
): S31-4
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Lung Macrophage Diversity and Asthma
#MMPMID27027949
Lumeng CN
Ann Am Thorac Soc
2016[Mar]; 13 Suppl 1
(Suppl 1
): S31-4
PMID27027949
show ga
Macrophages (MPs) are one of the most prominent leukocyte populations in the lung
and, in many ways, a forgotten player in asthma pathogenesis. Diverse functions
in asthma initiation and maintenance in chronic disease have been demonstrated,
which has led to confusion as to if pulmonary MPs are agents of good or evil in
asthma. Much of this is due to the wide diversity of MP populations in the lung,
many of which are inaccessible experimentally in most clinical studies. This
review frames lung MP biology in the context of location, phenotype, function,
and response phase in asthma pathogenesis. It also assesses new findings
regarding MP diversity that have challenged old dogmas and generates new ways to
understand how MPs function.