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2014 ; 40
(ä): 53
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Looking for new treatments of Infantile Colic
#MMPMID24898541
Savino F
; Ceratto S
; De Marco A
; Cordero di Montezemolo L
Ital J Pediatr
2014[Jun]; 40
(ä): 53
PMID24898541
show ga
Infantile colic is a common disturbance occurring in the first three months of
life. It is a benign condition and one of the main causes of pediatric
consultation in the early part of life because of its great impact on family
life. Some pediatricians are prone to undervalue this issue mainly because of the
lack of evidence based medicine guidelines. Up to now, there is no consensus
concerning management and treatment. Literature reports growing evidence about
the effectiveness of dietary, pharmacological, complementary and behavioral
therapies as options for the management of infantile colic. Dietary approach,
usually based on the avoidance of cow's milk proteins in breast-feeding mothers
and bottle-fed infants, more recently has seen the rise of new special formulas,
such as partially hydrolyzed proteins and low lactose added with prebiotics or
probiotics: their efficacy needs to be further documented. Investigated
pharmacological agents are Simethicone and Cimetropium Bromide: the first is able
to reduce bloating while the second could reduce fussing crying, but it has been
tested only for severe infantile colic. No other pain relieving agents have been
proposed until now, but some clinical trials are ongoing for new drugs.There is
limited evidence supporting the use of complementary and alternative treatments
(herbal supplements, manipulative approach and acupuncture) or behavioral
interventions.Recent studies have focused the role of microbiota in the
pathogenesis of this disturb and so new treatments, such as probiotics, have been
proposed, but only few strains have been tested.Further investigations are needed
in order to provide evidence-based guidelines.