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10.1016/j.heares.2014.09.003 http://scihub22266oqcxt.onion/10.1016/j.heares.2014.09.003 C4369472!4369472 !25245586     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25245586 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25245586 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hear+Res 2015 ; 322 (ä): 200-11 Nephropedia Template TP {{tp|p=25245586 |t=2015. Longitudinal performance of an implantable vestibular prosthesis |pdf=|usr=}}{{25245586 }} gab.com Text Longitudinal performance of an implantable vestibular prosthesis JO: Hear Res http://www.kidney.de/pget.php?&tw=1&pmid=25245586 #FOAvip Loss of vestibular function may be treatable with an implantable vestibular prosthesis that stimulates semicircular canal afferents with biphasic pulse trains. Several studies have demonstrated short-term activation of the vestibulo-ocular reflex (VOR) with electrical stimulation. Fewer long-term studies have been restricted to small numbers of animals and stimulation designed to produce adaptive changes in the electrically elicited response. This study is the first large consecutive series of implanted rhesus macaque to be studied longitudinally using brief stimuli designed to limit adaptive changes in response, so that the efficacy of electrical activation can be studied over time, across surgeries, canals and animals. The implantation of a vestibular prosthesis in animals with intact vestibular end organs produces variable responses to electrical stimulation across canals and animals, which change in threshold for electrical activation of eye movements and in elicited slow phase velocities over time. These thresholds are consistently lower, and the slow phase velocities higher, than those obtained in human subjects. The changes do not appear to be correlated with changes in electrode impedance. The variability in response suggests that empirically derived transfer functions may be required to optimize the response of individual canals to a vestibular prosthesis, and that this function may need to be remapped over time. This article is part of a Special Issue entitled <Lasker Award>. Twit Text FOAVip Longitudinal performance of an implantable vestibular prosthesis ????Hear Res http://www.kidney.de/pget.php?&tw=1&pmid=25245586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25245586 #FOAvip English Wikipedia <ref>{{Cite pmid|25245586 }}</ref> Longitudinal performance of an implantable vestibular prosthesis #MMPMID25245586 Phillips C ; Ling L ; Oxford T ; Nowack A ; Nie K ; Rubinstein JT ; Phillips JO Hear Res 2015[Apr]; 322 (ä): 200-11 PMID25245586 show ga Loss of vestibular function may be treatable with an implantable vestibular prosthesis that stimulates semicircular canal afferents with biphasic pulse trains. Several studies have demonstrated short-term activation of the vestibulo-ocular reflex (VOR) with electrical stimulation. Fewer long-term studies have been restricted to small numbers of animals and stimulation designed to produce adaptive changes in the electrically elicited response. This study is the first large consecutive series of implanted rhesus macaque to be studied longitudinally using brief stimuli designed to limit adaptive changes in response, so that the efficacy of electrical activation can be studied over time, across surgeries, canals and animals. The implantation of a vestibular prosthesis in animals with intact vestibular end organs produces variable responses to electrical stimulation across canals and animals, which change in threshold for electrical activation of eye movements and in elicited slow phase velocities over time. These thresholds are consistently lower, and the slow phase velocities higher, than those obtained in human subjects. The changes do not appear to be correlated with changes in electrode impedance. The variability in response suggests that empirically derived transfer functions may be required to optimize the response of individual canals to a vestibular prosthesis, and that this function may need to be remapped over time. This article is part of a Special Issue entitled . |*Eye Movements [MESH] |*Neural Prostheses [MESH] |*Postural Balance [MESH] |Animals [MESH] |Behavior, Animal [MESH] |Electric Impedance [MESH] |Electric Stimulation [MESH] |Macaca mulatta [MESH] |Materials Testing [MESH] |Models, Animal [MESH] |Nystagmus, Physiologic [MESH] |Prosthesis Design [MESH] |Prosthesis Implantation/*instrumentation [MESH] |Time Factors [MESH]Longitudinal performance of an implantable vestibular prosthesis (epmc).pdf DeepDyve Pubget Overpricing