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2015 ; 12
(3
): 415-40
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Long-term delivery of protein therapeutics
#MMPMID25251334
Vaishya R
; Khurana V
; Patel S
; Mitra AK
Expert Opin Drug Deliv
2015[Mar]; 12
(3
): 415-40
PMID25251334
show ga
INTRODUCTION: Proteins are effective biotherapeutics with applications in diverse
ailments. Despite being specific and potent, their full clinical potential has
not yet been realized. This can be attributed to short half-lives, complex
structures, poor in vivo stability, low permeability, frequent parenteral
administrations and poor adherence to treatment in chronic diseases. A sustained
release system, providing controlled release of proteins, may overcome many of
these limitations. AREAS COVERED: This review focuses on recent development in
approaches, especially polymer-based formulations, which can provide therapeutic
levels of proteins over extended periods. Advances in particulate, gel-based
formulations and novel approaches for extended protein delivery are discussed.
Emphasis is placed on dosage form, method of preparation, mechanism of release
and stability of biotherapeutics. EXPERT OPINION: Substantial advancements have
been made in the field of extended protein delivery via various polymer-based
formulations over last decade despite the unique delivery-related challenges
posed by protein biologics. A number of injectable sustained-release formulations
have reached market. However, therapeutic application of proteins is still
hampered by delivery-related issues. A large number of protein molecules are
under clinical trials, and hence, there is an urgent need to develop new methods
to deliver these highly potent biologics.
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