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2016 ; 4
(ä): 53
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English Wikipedia
Long-term Outcomes of Childhood Onset Nephrotic Syndrome
#MMPMID27252935
Hjorten R
; Anwar Z
; Reidy KJ
Front Pediatr
2016[]; 4
(ä): 53
PMID27252935
show ga
There are limited studies on long-term outcomes of childhood onset nephrotic
syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic
syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a
high risk of developing end-stage renal disease. Biomarkers and analysis of
genetic mutations may provide new information for prognosis in SRNS. Frequently
relapsing and steroid-dependent NS is associated with long-term complications,
including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired
growth, and infertility. Long-term complications of SSNS are likely to be
under-recognized. There remain many gaps in our knowledge of long-term outcomes
of childhood NS, and further study is indicated.