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10.1016/bs.ai.2015.07.003 http://scihub22266oqcxt.onion/10.1016/bs.ai.2015.07.003 C4660984!4660984 !26477367     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26477367 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Immunol 2015 ; 128 (ä): 123-82 Nephropedia Template TP {{tp|p=26477367 |t=2015. Long-Range Regulation of V(D)J Recombination |pdf=|usr=}}{{26477367 }} gab.com Text Long-Range Regulation of V(D)J Recombination JO: Adv Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26477367 #FOAvip Given their essential role in adaptive immunity, antigen receptor loci have been the focus of analysis for many years and are among a handful of the most well-studied genes in the genome. Their investigation led initially to a detailed knowledge of linear structure and characterization of regulatory elements that confer control of their rearrangement and expression. However, advances in DNA FISH and imaging combined with new molecular approaches that interrogate chromosome conformation have led to a growing appreciation that linear structure is only one aspect of gene regulation and in more recent years, the focus has switched to analyzing the impact of locus conformation and nuclear organization on control of recombination. Despite decades of work and intense effort from numerous labs, we are still left with an incomplete picture of how the assembly of antigen receptor loci is regulated. This chapter summarizes our advances to date and points to areas that need further investigation. Twit Text FOAVip Long-Range Regulation of V(D)J Recombination ????Adv Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26477367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26477367 #FOAvip English Wikipedia <ref>{{Cite pmid|26477367 }}</ref> Long-Range Regulation of V(D)J Recombination #MMPMID26477367 Proudhon C ; Hao B ; Raviram R ; Chaumeil J ; Skok JA Adv Immunol 2015[]; 128 (ä): 123-82 PMID26477367 show ga Given their essential role in adaptive immunity, antigen receptor loci have been the focus of analysis for many years and are among a handful of the most well-studied genes in the genome. Their investigation led initially to a detailed knowledge of linear structure and characterization of regulatory elements that confer control of their rearrangement and expression. However, advances in DNA FISH and imaging combined with new molecular approaches that interrogate chromosome conformation have led to a growing appreciation that linear structure is only one aspect of gene regulation and in more recent years, the focus has switched to analyzing the impact of locus conformation and nuclear organization on control of recombination. Despite decades of work and intense effort from numerous labs, we are still left with an incomplete picture of how the assembly of antigen receptor loci is regulated. This chapter summarizes our advances to date and points to areas that need further investigation. |*Enhancer Elements, Genetic [MESH] |*V(D)J Recombination [MESH] |Animals [MESH] |Humans [MESH] |Immunoglobulin Heavy Chains/genetics [MESH] |In Situ Hybridization, Fluorescence [MESH]Long-Range Regulation of V(D)J Recombination (epmc).pdf DeepDyve Pubget Overpricing