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2016 ; 8
(6
): 1234-44
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Long term complications following 54 consecutive lung transplants
#MMPMID27293842
Tabarelli W
; Bonatti H
; Tabarelli D
; Eller M
; Müller L
; Ruttmann E
; Lass-Flörl C
; Larcher C
; Geltner C
J Thorac Dis
2016[Jun]; 8
(6
): 1234-44
PMID27293842
show ga
BACKGROUND: Due to the complex therapy and the required high level of
immunosuppression, lung recipients are at high risk to develop many different
long term complications. METHODS: From 1993-2000, a total of 54 lung
transplantation (LuTx) were performed at our center. Complications, graft and
patient survival of this cohort was retrospectively analyzed. RESULTS: One/five
and ten-year patient survival was 71.4%, 41.2% and 25.4%; at last follow up
(4/2010), twelve patients were alive. Of the 39 deceased patients, 26 died from
infectious complications. Other causes of death were myocardial infarction (n=1),
progressive graft failure (n=1), intracerebral bleeding (n=2), basilary vein
thrombosis (n=1), pulmonary emboli (n=1), others (n=7). Surgical complication
rate was 27.7% during the first year and 25% for the 12 long term survivors.
Perioperative rejection rate was 35%, and 91.6% for the 12 patients currently
alive. Infection incidence during first hospitalization was 79.6% (1.3 episodes
per transplant) and 100% for long term survivors. Commonly isolated pathogens
were cytomegalovirus (56.8%), Aspergillus (29.4%), RSV (13.7%). Other common
complications were renal failure (56.8%), osteoporosis (54.9%), hypertension
(45%), diabetes mellitus (19.6%). CONCLUSIONS: Infection and rejection remain the
most common complications following LuTx with many other events to be considered.