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10.21037/jtd.2016.05.03

http://scihub22266oqcxt.onion/10.21037/jtd.2016.05.03
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suck abstract from ncbi


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pmid27293842
      J+Thorac+Dis 2016 ; 8 (6 ): 1234-44
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  • Long term complications following 54 consecutive lung transplants #MMPMID27293842
  • Tabarelli W ; Bonatti H ; Tabarelli D ; Eller M ; Müller L ; Ruttmann E ; Lass-Flörl C ; Larcher C ; Geltner C
  • J Thorac Dis 2016[Jun]; 8 (6 ): 1234-44 PMID27293842 show ga
  • BACKGROUND: Due to the complex therapy and the required high level of immunosuppression, lung recipients are at high risk to develop many different long term complications. METHODS: From 1993-2000, a total of 54 lung transplantation (LuTx) were performed at our center. Complications, graft and patient survival of this cohort was retrospectively analyzed. RESULTS: One/five and ten-year patient survival was 71.4%, 41.2% and 25.4%; at last follow up (4/2010), twelve patients were alive. Of the 39 deceased patients, 26 died from infectious complications. Other causes of death were myocardial infarction (n=1), progressive graft failure (n=1), intracerebral bleeding (n=2), basilary vein thrombosis (n=1), pulmonary emboli (n=1), others (n=7). Surgical complication rate was 27.7% during the first year and 25% for the 12 long term survivors. Perioperative rejection rate was 35%, and 91.6% for the 12 patients currently alive. Infection incidence during first hospitalization was 79.6% (1.3 episodes per transplant) and 100% for long term survivors. Commonly isolated pathogens were cytomegalovirus (56.8%), Aspergillus (29.4%), RSV (13.7%). Other common complications were renal failure (56.8%), osteoporosis (54.9%), hypertension (45%), diabetes mellitus (19.6%). CONCLUSIONS: Infection and rejection remain the most common complications following LuTx with many other events to be considered.
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