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2016 ; 13
(2
): 138-47
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Long noncoding RNAs in innate immunity
#MMPMID26277893
Zhang Y
; Cao X
Cell Mol Immunol
2016[Mar]; 13
(2
): 138-47
PMID26277893
show ga
Long noncoding RNAs (lncRNAs) have been shown to play important roles in immune
cell development and immune responses through different mechanisms, such as
dosage compensation, imprinting, enhancer function, and transcriptional
regulation. Although the functions of most lncRNAs are unclear, some lncRNAs have
been found to control transcriptional or post-transcriptional regulation of the
innate and adaptive immune responses via new methods of protein-protein
interactions or pairing with DNA and RNA. Interestingly, increasing evidence has
elucidated the importance of lncRNAs in the interaction between hosts and
pathogens. In this review, an overview of the lncRNAs modes of action, as well as
the important and diversified roles of lncRNAs in immunity, are provided, and an
emerging paradigm of lncRNAs in regulating innate immune responses is
highlighted.