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2018 ; 51
(6
): 280-289
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Long noncoding RNA: multiple players in gene expression
#MMPMID29636120
Chen X
; Sun Y
; Cai R
; Wang G
; Shu X
; Pang W
BMB Rep
2018[Jun]; 51
(6
): 280-289
PMID29636120
show ga
Previously considered as a component of transcriptional noise, long noncoding
RNAs (lncRNAs) were neglected as a therapeutic target, however, recently
increasing evidence has shown that lncRNAs can participate in numerous biological
processes involved in genetic regulation including epigenetic, transcriptional,
and post-transcriptional regulation. In this review, we discuss the fundamental
functions of lncRNAs at different regulatory levels and their roles in metabolic
balance. Typical examples are introduced to illustrate their diverse molecular
mechanisms. The comprehensive investigation and identification of key lncRNAs
will not only contribute to insights into diseases, such as breast cancer and
type II diabetes, but also provide promising therapeutic targets for related
diseases. [BMB Reports 2018; 51(6): 280-289].