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2014 ; 60
(2
): 744-53
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Long noncoding RNA in liver diseases
#MMPMID24493213
Takahashi K
; Yan I
; Haga H
; Patel T
Hepatology
2014[Aug]; 60
(2
): 744-53
PMID24493213
show ga
The identification of the presence of large RNA transcripts that do not code for
proteins but that may have biological functions has provided an important new
perspective in gene regulation. These long noncoding RNAs (lncRNAs) are being
increasingly recognized to contribute to many biological processes through
diverse mechanisms. The roles of these emerging genes are being recognized across
kingdoms. These findings are profoundly altering our understanding of disease
pathobiology and leading to the emergence of new biological concepts underlying
human diseases. Strategies for the discovery and characterization of lncRNAs are
highlighted. Several lncRNAs have been described in liver disease, and in liver
cancers in particular. Their molecular mechanisms of action, function, and
contributions to disease pathophysiology are reviewed. LncRNA genes associated
with liver diseases have potential roles as biomarkers of disease diagnosis,
prognosis, or therapeutic response as well as direct targets for therapeutic
intervention. CONCLUSION: The emerging knowledge in this rapidly advancing field
offers promise for new fundamental knowledge and clinical applications that will
be relevant for human liver diseases.
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