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10.1073/pnas.1525022113 http://scihub22266oqcxt.onion/10.1073/pnas.1525022113 C5027408!5027408 !27582466     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27582466 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (37 ): 10388-93 Nephropedia Template TP {{tp|p=27582466 |t=2016. Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression |pdf=|usr=}}{{27582466 }} gab.com Text Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27582466 #FOAvip Despite the breadth of knowledge that exists regarding the function of long noncoding RNAs (lncRNAs) in biological phenomena, the role of lncRNAs in host antiviral responses is poorly understood. Here, we report that lncRNA#32 is associated with type I IFN signaling. The silencing of lncRNA#32 dramatically reduced the level of IFN-stimulated gene (ISG) expression, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, the ectopic expression of lncRNA#32 significantly suppressed EMCV replication, suggesting that lncRNA#32 positively regulates the host antiviral response. We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses. Twit Text FOAVip Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27582466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27582466 #FOAvip English Wikipedia <ref>{{Cite pmid|27582466 }}</ref> Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression #MMPMID27582466 Nishitsuji H ; Ujino S ; Yoshio S ; Sugiyama M ; Mizokami M ; Kanto T ; Shimotohno K Proc Natl Acad Sci U S A 2016[Sep]; 113 (37 ): 10388-93 PMID27582466 show ga Despite the breadth of knowledge that exists regarding the function of long noncoding RNAs (lncRNAs) in biological phenomena, the role of lncRNAs in host antiviral responses is poorly understood. Here, we report that lncRNA#32 is associated with type I IFN signaling. The silencing of lncRNA#32 dramatically reduced the level of IFN-stimulated gene (ISG) expression, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, the ectopic expression of lncRNA#32 significantly suppressed EMCV replication, suggesting that lncRNA#32 positively regulates the host antiviral response. We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses. |Activating Transcription Factor 2/*genetics/metabolism [MESH] |Cardiovirus Infections/genetics/virology [MESH] |Cell Line, Tumor [MESH] |Encephalomyocarditis virus/genetics/pathogenicity [MESH] |Gene Expression Regulation [MESH] |Gene Silencing [MESH] |Hepacivirus/genetics/pathogenicity [MESH] |Hepatitis C/genetics/virology [MESH] |Hepatocytes/metabolism/virology [MESH] |Host-Pathogen Interactions/*genetics [MESH] |Humans [MESH] |Interferon Type I/*genetics/metabolism [MESH] |RNA, Long Noncoding/*genetics/metabolism [MESH] |Signal Transduction/genetics [MESH]Long noncoding RNA #32 contributes to antiviral responses by controlli(epmc).pdf DeepDyve Pubget Overpricing