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2017 ; 8
(10
): e3073
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Long non-coding RNAs involved in autophagy regulation
#MMPMID28981093
Yang L
; Wang H
; Shen Q
; Feng L
; Jin H
Cell Death Dis
2017[Oct]; 8
(10
): e3073
PMID28981093
show ga
Autophagy degrades non-functioning or damaged proteins and organelles to maintain
cellular homeostasis in a physiological or pathological context. Autophagy can be
protective or detrimental, depending on its activation status and other
conditions. Therefore, autophagy has a crucial role in a myriad of
pathophysiological processes. From the perspective of autophagy-related (ATG)
genes, the molecular dissection of autophagy process and the regulation of its
level have been largely unraveled. However, the discovery of long non-coding RNAs
(lncRNAs) provides a new paradigm of gene regulation in almost all important
biological processes, including autophagy. In this review, we highlight recent
advances in autophagy-associated lncRNAs and their specific autophagic targets,
as well as their relevance to human diseases such as cancer, cardiovascular
disease, diabetes and cerebral ischemic stroke.