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2017 ; 8
(12
): 20462-20475
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Long non-coding RNAs in osteosarcoma
#MMPMID28103585
Chen R
; Wang G
; Zheng Y
; Hua Y
; Cai Z
Oncotarget
2017[Mar]; 8
(12
): 20462-20475
PMID28103585
show ga
Long non-coding RNAs (lncRNAs) with more than 200 nuleotides, have been explored
to participate in various cancer types including osteosarcoma (OS), which is the
most common kind of primary bone tumors with high morbidity in infants and
adolescents. These oncogenic or tumor suppressive lncRNAs regulate OS
pathogenesis, such as cell growth, proliferation, invasion, migration, metastasis
and cell apoptosis, serve as independent prognostic biomarkers or play a
significant role in multidrug resistance (MDR) in OS cells. In this review, we
attempt to dissect the participation of lncRNAs in pathogenesis of OS and their
potential clinical values, and also provide an outlook for viable biomarkers and
therapeutic targets in OS.