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2017 ; 8
(16
): 27582-27592
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Long non-coding RNA in glioma: signaling pathways
#MMPMID28187439
Shi J
; Dong B
; Cao J
; Mao Y
; Guan W
; Peng Y
; Wang S
Oncotarget
2017[Apr]; 8
(16
): 27582-27592
PMID28187439
show ga
Glioma is regarded as the most prevalent malignant carcinoma of the central
nervous system. Thus, the development of new therapeutic strategies targeting
glioma is of significant clinical importance. Long non-coding RNAs (lncRNAs) are
functional RNA molecules without a protein-coding function and are reportedly
involved in the initiation and progression of glioma. Dysregulation of lncRNAs in
glioma is due to activation of several signaling pathways, such as the
BRD4-HOTAIR-?-catenin/PDCD4, p53-Hif-H19/IGF2 and CRNDE/mTOR pathways.
Furthermore, microRNAs (miRNAs) such as miR-675 also interact with lncRNAs in
glioma. Thus, exploring the mechanisms by which lncRNA control processes will be
instrumental for devising new effective therapies against glioma.
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