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2016 ; 14
(4
): 191-9
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Long non-coding RNA Databases in Cardiovascular Research
#MMPMID27049585
Rühle F
; Stoll M
Genomics Proteomics Bioinformatics
2016[Aug]; 14
(4
): 191-9
PMID27049585
show ga
With the rising interest in the regulatory functions of long non-coding RNAs
(lncRNAs) in complex human diseases such as cardiovascular diseases, there is an
increasing need in public databases offering comprehensive and integrative data
for all aspects of these versatile molecules. Recently, a variety of public data
repositories that specialized in lncRNAs have been developed, which make use of
huge high-throughput data particularly from next-generation sequencing (NGS)
approaches. Here, we provide an overview of current lncRNA databases covering
basic and functional annotation, lncRNA expression and regulation, interactions
with other biomolecules, and genomic variants influencing the structure and
function of lncRNAs. The prominent lncRNA antisense noncoding RNA in the INK4
locus (ANRIL), which has been unequivocally associated with coronary artery
disease through genome-wide association studies (GWAS), serves as an example to
demonstrate the features of each individual database.
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