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2016 ; 29
(4
): 452-463
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Long Noncoding RNAs in Cancer Pathways
#MMPMID27070700
Schmitt AM
; Chang HY
Cancer Cell
2016[Apr]; 29
(4
): 452-463
PMID27070700
show ga
Genome-wide cancer mutation analyses are revealing an extensive landscape of
functional mutations within the noncoding genome, with profound effects on the
expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of
lncRNA transcription can provide signals of malignant transformation, we now
understand that lncRNAs drive many important cancer phenotypes through their
interactions with other cellular macromolecules including DNA, protein, and RNA.
Recent advancements in surveying lncRNA molecular mechanisms are now providing
the tools to functionally annotate these cancer-associated transcripts, making
these molecules attractive targets for therapeutic intervention in the fight
against cancer.
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