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2016 ; 12
(7
): 898-910
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Long Noncoding RNA: Recent Updates in Atherosclerosis
#MMPMID27314829
Li H
; Zhu H
; Ge J
Int J Biol Sci
2016[]; 12
(7
): 898-910
PMID27314829
show ga
Long noncoding RNAs belong to a class of noncoding RNAs longer than 200
nucleotides with the epigenetic regulation potential. As a novel molecular
regulator, lncRNAs are often dysregulated in various pathological conditions and
display multiple functions in a wide range of biological processes. Given that
recent studies have indicated that lncRNAs are involved in
atherosclerosis-related smooth muscle cell, endothelial cell, macrophage and
lipid metabolism regulation, it is pertinent to understand the potential function
of lncRNAs in atherosclerosis development. This review will highlight the recent
updates of lncRNAs in atherogenesis and also discuss their potential roles as
novel therapeutic targets.