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2016 ; 14
(2
): 73-80
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Long Non-coding RNAs in the Cytoplasm
#MMPMID27163185
Rashid F
; Shah A
; Shan G
Genomics Proteomics Bioinformatics
2016[Apr]; 14
(2
): 73-80
PMID27163185
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An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic
genome are important regulators in different aspects of cellular events.
Cytoplasm is the residence and the site of action for many lncRNAs. The
cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms
in animal and human cells. In this review, we mainly talk about functions and the
underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively
well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA
stability, regulating mRNA translation, serving as competing endogenous RNAs,
functioning as precursors of microRNAs, and mediating protein modifications. We
also elaborate the perspectives of cytoplasmic lncRNA studies.