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10.1038/nature19325 http://scihub22266oqcxt.onion/10.1038/nature19325 C5161591!5161591 !27602521     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27602521 &cmd=llinks): Failed to open stream: HTTP request failed! 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Locus coeruleus and dopaminergic consolidation of everyday memory |pdf=|usr=}}{{27602521 }} gab.com Text Locus coeruleus and dopaminergic consolidation of everyday memory JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=27602521 #FOAvip The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH(+)) neurons in the ventral tegmental area. Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental novelty, locus coeruleus TH(+) neurons project more profusely than ventral tegmental area TH(+) neurons to the hippocampus, optogenetic activation of locus coeruleus TH(+) neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by ventral tegmental area inactivation. Surprisingly, two effects of locus coeruleus TH(+) photoactivation are sensitive to hippocampal D(1)/D(5) receptor blockade and resistant to adrenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, locus coeruleus TH(+) neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus. Twit Text FOAVip Locus coeruleus and dopaminergic consolidation of everyday memory ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=27602521 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602521 #FOAvip English Wikipedia <ref>{{Cite pmid|27602521 }}</ref> Locus coeruleus and dopaminergic consolidation of everyday memory #MMPMID27602521 Takeuchi T ; Duszkiewicz AJ ; Sonneborn A ; Spooner PA ; Yamasaki M ; Watanabe M ; Smith CC ; Fernández G ; Deisseroth K ; Greene RW ; Morris RG Nature 2016[Sep]; 537 (7620 ): 357-362 PMID27602521 show ga The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH(+)) neurons in the ventral tegmental area. Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental novelty, locus coeruleus TH(+) neurons project more profusely than ventral tegmental area TH(+) neurons to the hippocampus, optogenetic activation of locus coeruleus TH(+) neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by ventral tegmental area inactivation. Surprisingly, two effects of locus coeruleus TH(+) photoactivation are sensitive to hippocampal D(1)/D(5) receptor blockade and resistant to adrenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, locus coeruleus TH(+) neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus. |Animals [MESH] |CA1 Region, Hippocampal/cytology/drug effects/physiology [MESH] |Dopamine/*metabolism [MESH] |In Vitro Techniques [MESH] |Locus Coeruleus/cytology/*physiology/radiation effects [MESH] |Male [MESH] |Memory Consolidation/drug effects/*physiology/radiation effects [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Neurons/metabolism/radiation effects [MESH] |Optogenetics [MESH] |Receptors, Adrenergic/metabolism [MESH] |Receptors, Dopamine D1/antagonists & inhibitors/metabolism [MESH] |Receptors, Dopamine D5/antagonists & inhibitors/metabolism [MESH] |Synaptic Transmission/drug effects [MESH]Locus coeruleus and dopaminergic consolidation of everyday memory (epmc).pdf DeepDyve Pubget Overpricing