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10.1038/nchem.2828 http://scihub22266oqcxt.onion/10.1038/nchem.2828 C5669467!5669467 !29064488     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29064488 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Chem 2017 ; 9 (11 ): 1110-1117 Nephropedia Template TP {{tp|p=29064488 |t=2017. Local epigenetic reprogramming induced by G-quadruplex ligands |pdf=|usr=}}{{29064488 }} gab.com Text Local epigenetic reprogramming induced by G-quadruplex ligands JO: Nat Chem http://www.kidney.de/pget.php?&tw=1&pmid=29064488 #FOAvip DNA and histone modifications regulate transcriptional activity and thus represent valuable targets to reprogram the activity of genes. Current epigenetic therapies target the machinery that regulates these modifications, leading to global transcriptional reprogramming with the potential for extensive undesired effects. Epigenetic information can also be modified as a consequence of disrupting processive DNA replication. Here, we demonstrate that impeding replication by small-molecule-mediated stabilization of G-quadruplex nucleic acid secondary structures triggers local epigenetic plasticity. We report the use of the BU-1 locus of chicken DT40 cells to screen for small molecules able to induce G-quadruplex-dependent transcriptional reprogramming. Further characterization of the top hit compound revealed its ability to induce a dose-dependent inactivation of BU-1 expression in two steps: the loss of H3K4me3 and then subsequent DNA cytosine methylation, changes that were heritable across cell divisions even after the compound was removed. Targeting DNA secondary structures thus represents a potentially new approach for locus-specific epigenetic reprogramming. Twit Text FOAVip Local epigenetic reprogramming induced by G-quadruplex ligands ????Nat Chem http://www.kidney.de/pget.php?&tw=1&pmid=29064488 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29064488 #FOAvip English Wikipedia <ref>{{Cite pmid|29064488 }}</ref> Local epigenetic reprogramming induced by G-quadruplex ligands #MMPMID29064488 Guilbaud G ; Murat P ; Recolin B ; Campbell BC ; Maiter A ; Sale JE ; Balasubramanian S Nat Chem 2017[Nov]; 9 (11 ): 1110-1117 PMID29064488 show ga DNA and histone modifications regulate transcriptional activity and thus represent valuable targets to reprogram the activity of genes. Current epigenetic therapies target the machinery that regulates these modifications, leading to global transcriptional reprogramming with the potential for extensive undesired effects. Epigenetic information can also be modified as a consequence of disrupting processive DNA replication. Here, we demonstrate that impeding replication by small-molecule-mediated stabilization of G-quadruplex nucleic acid secondary structures triggers local epigenetic plasticity. We report the use of the BU-1 locus of chicken DT40 cells to screen for small molecules able to induce G-quadruplex-dependent transcriptional reprogramming. Further characterization of the top hit compound revealed its ability to induce a dose-dependent inactivation of BU-1 expression in two steps: the loss of H3K4me3 and then subsequent DNA cytosine methylation, changes that were heritable across cell divisions even after the compound was removed. Targeting DNA secondary structures thus represents a potentially new approach for locus-specific epigenetic reprogramming. |*G-Quadruplexes [MESH] |DNA/*genetics [MESH] |Epigenesis, Genetic/*genetics [MESH] |Ligands [MESH]Local epigenetic reprogramming induced by G-quadruplex ligands (epmc).pdf DeepDyve Pubget Overpricing