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10.1038/srep14554 http://scihub22266oqcxt.onion/10.1038/srep14554 C4586607!4586607!26416623     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26416623.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26416623|t=2015. Local bacteria affect the efficacy of chemotherapeutic drugs |pdf=|usr=}}{{26416623}} gab.com Text Local bacteria affect the efficacy of chemotherapeutic drugs JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26416623 #FOAvip In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and cancer cell lines were examined in vitro and in vivo for changes in the efficacy of cancer cell killing mediated by chemotherapeutic agents. Of 30 drugs examined in vitro, the efficacy of 10 was found to be significantly inhibited by certain bacteria, while the same bacteria improved the efficacy of six others. HPLC and mass spectrometry analyses of sample drugs (gemcitabine, fludarabine, cladribine, CB1954) demonstrated modification of drug chemical structure. The chemoresistance or increased cytotoxicity observed in vitro with sample drugs (gemcitabine and CB1954) was replicated in in vivo murine subcutaneous tumour models. These findings suggest that bacterial presence in the body due to systemic or local infection may influence tumour responses or off-target toxicity during chemotherapy. Twit Text FOAVip Local bacteria affect the efficacy of chemotherapeutic drugs ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26416623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26416623 #FOAvip English Wikipedia <ref>{{Cite pmid|26416623}}</ref> Local bacteria affect the efficacy of chemotherapeutic drugs #MMPMID26416623 Lehouritis P; Cummins J; Stanton M; Murphy CT; McCarthy FO; Reid G; Urbaniak C; Byrne WL; Tangney M Sci Rep 2015[]; 5 (ä): ä PMID26416623show ga In this study, the potential effects of bacteria on the efficacy of frequently used chemotherapies was examined. Bacteria and cancer cell lines were examined in vitro and in vivo for changes in the efficacy of cancer cell killing mediated by chemotherapeutic agents. Of 30 drugs examined in vitro, the efficacy of 10 was found to be significantly inhibited by certain bacteria, while the same bacteria improved the efficacy of six others. HPLC and mass spectrometry analyses of sample drugs (gemcitabine, fludarabine, cladribine, CB1954) demonstrated modification of drug chemical structure. The chemoresistance or increased cytotoxicity observed in vitro with sample drugs (gemcitabine and CB1954) was replicated in in vivo murine subcutaneous tumour models. These findings suggest that bacterial presence in the body due to systemic or local infection may influence tumour responses or off-target toxicity during chemotherapy. äLocal bacteria affect the efficacy of chemotherapeutic drugs (epmc).pdf DeepDyve Pubget Overpricing