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Local bacteria affect the efficacy of chemotherapeutic drugs
#MMPMID26416623
Lehouritis P
; Cummins J
; Stanton M
; Murphy CT
; McCarthy FO
; Reid G
; Urbaniak C
; Byrne WL
; Tangney M
Sci Rep
2015[Sep]; 5
(?): 14554
PMID26416623
show ga
In this study, the potential effects of bacteria on the efficacy of frequently
used chemotherapies was examined. Bacteria and cancer cell lines were examined in
vitro and in vivo for changes in the efficacy of cancer cell killing mediated by
chemotherapeutic agents. Of 30 drugs examined in vitro, the efficacy of 10 was
found to be significantly inhibited by certain bacteria, while the same bacteria
improved the efficacy of six others. HPLC and mass spectrometry analyses of
sample drugs (gemcitabine, fludarabine, cladribine, CB1954) demonstrated
modification of drug chemical structure. The chemoresistance or increased
cytotoxicity observed in vitro with sample drugs (gemcitabine and CB1954) was
replicated in in vivo murine subcutaneous tumour models. These findings suggest
that bacterial presence in the body due to systemic or local infection may
influence tumour responses or off-target toxicity during chemotherapy.
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