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2016 ; 95
(20
): e3713
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Local Immune Response in Helicobacter pylori Infection
#MMPMID27196487
Kivrak Salim D
; Sahin M
; Köksoy S
; Adanir H
; Süleymanlar I
Medicine (Baltimore)
2016[May]; 95
(20
): e3713
PMID27196487
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There have been few studies concerning the cytokine profiles in gastric mucosa of
Helicobacter pylori-infected patients with normal mucosa, chronic gastritis, and
gastric carcinoma (GAC).In the present study, we aimed to elucidate the genomic
expression levels and immune pathological roles of cytokines-interferon (IFN)-?,
tumor necrosis factor (TNF)-?, interleukin (IL)-4, IL-6, IL-10, transforming
growth factor (TGF)-?, IL-17A, IL-32-in H pylori-infected patients with normal
gastric mucosa (NGM; control), chronic active gastritis (CAG), and GAC. Genomic
expression levels of these cytokines were assayed by real-time PCR analysis in
gastric biopsy specimens obtained from 93 patients.We found that the genomic
expression levels of IFN-?, TNF-?, IL-6, IL-10, IL-17A mRNA were increased in the
CAG group and those of TNF-?, IL-6, IL-10, IL-17A, TGF-? mRNA were increased in
the GAC group with reference to H pylori-infected NGM group.This study is on the
interest of cytokine profiles in gastric mucosa among individuals with normal,
gastritis, or GAC. Our findings suggest that the immune response of gastric
mucosa to infection of H pylori differs from patient to patient. For individual
therapy, levels of genomic expression of IL-6 or other cytokines may be tracked
in patients.
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